PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

Principal Investigator: Jiafu Ou
Study Coordinator / Research Nurse: Marie White

This study is currently enrolling participants. To learn more about PREVENTABLE and how you can join contact our research office at (314) 289-7690

This study is funded by the Foundation through NIH and Duke University 

As of August 6, 2021, the St. Louis VA has the 2nd highest enrolled VA site; there are 74 activated sites (VA and Non-VA) 1579 participants enrolled and 1460 randomized.

For years, doctors have looked for treatments to prevent memory loss or dementia in patients. Some studies suggest drugs that lower cholesterol, also called statins, may help prevent dementia. But more information is needed to understand the role and benefits of statins for older adults.

 PREVENTABLE researchers are partnering with the Alzheimer’s Association to make this study opportunity available to adults interested in advancing research on dementia. By participating in studies such as PREVENTABLE, you can help doctors learn if taking a statin can prevent dementia. Without the participation of people like you in studies, finding a cure is nearly impossible.

​About one in three of people in the U.S. over the age 75 without heart disease take statins. “Very few people start a statin after age 75 because we don’t have any proof that this drug improves the health of older adults,” said Alexander. “Results from PREVENTABLE will provide that evidence and help us understand if it makes sense to start a stain after the age of 75 to prevent dementia.”

Watch this video to learn why this study is important. To find out if your doctor or health system is participating in PREVENTABLE, visit www.preventabletrial.org
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St. Louis Preventable team. Marie White, Dr. Jiafu Ou, and Dr. Michael Kraujalis.