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Our Mission

The mission of the Veterans Research and Education Foundation of St. Louis is to improve the health and well-being of Veterans through research and education conducted within the VA St. Louis Health Care System.

A Multicenter, Randomized, Double-blind, Placebo controlled, Phase 2 Study Evaluating the Safety and Efficacy of Different Doses of IW-1973 over 12 Weeks in Patients with Heart Failure with Preserved Ejection Fraction

This Phase 2 study is about testing  the safety of the investigational oral drug IW-1973 (Praliciguat), compared to a placebo, and its effect on the ability to exercise after being taken for 12 weeks. In addition, explore the effect of the oral IW-1973 on the heart function, quality of life, health status, biomarkers and pharmacokinetics of the oral IW-1973 for 12 weeks.

PI: Dr. Ilia Halatchev

Study Coordinator: Marie White

This study is now closed to enrollment.