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Our Mission

The mission of the Veterans Research and Education Foundation of St. Louis is to improve the health and well-being of Veterans through research and education conducted within the VA St. Louis Health Care System.

A randomized phase III study using 177Lu-PSMA-617 as a radioligand therapy in the treatment of patients with progressive, PSMA positive, metastatic castration resistant prostate cancer

The primary objective of this study is to compare overall survival (OS) in patients with progressive PSMA-positive mCRPC who receive 177Lu-PSMA-617 in addition to best supportive/best standard of care versus patients treated with best supportive/best standard of care alone.

Key secondary objectives are an arm-to-arm comparison of the following:

  • Radiographic progression-free survival (rPFS)
  • Response Evaluation Criteria in Solid Tumors (RECIST) response
  • Time to a first symptomatic skeletal event (SSE)

PI: Dr. Medhat Osman

Study Coordinator: Kelly Reno

This study is now closed to enrollment.