Arm Exercise versus Pharmacologic Stress Testing for Clinical Outcome Prediction
The main objective of the Arm Exercise study is to assess whether arm exercise stress testing is non-inferior to Treadmill or Chemical stress testing
Treadmill exercise capacity and other physiologic responses to leg exercise are powerful predictors of mortality and provide important clinical and diagnostic information. However, many Veterans cannot perform treadmill exercise because of lower extremity or other disabilities. For many years, pharmacologic myocardial perfusion imaging (MPI) has been the standard of care for their evaluation but fails to provide powerful prognostic and clinically relevant information of exercise testing, requires exposure to ionizing radiation, and is several times more expensive than exercise electrocardiography (ECG). With a recently completed Merit Review award, we obtained substantial retrospective observational evidence that arm exercise ECG stress testing scores are at least equivalent to pharmacologic MPI for robust prediction of mortality and other measures of clinical outcome in Veterans who cannot perform leg exercise.
PI: Dr.Wade Martin
Study Coordinator: Maria Woodson
This study is currently enrolling. To learn more about the Arm Exercise Study and how you can join contact our research office at (314) 289-7690.