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Our Mission

The mission of the Veterans Research and Education Foundation of St. Louis is to improve the health and well-being of Veterans through research and education conducted within the VA St. Louis Health Care System.

Arm Exercise versus Pharmacologic Stress Testing for Clinical Outcome Prediction

The main objective of the Arm Exercise study is to assess whether arm exercise stress testing is non-inferior to Treadmill or Chemical stress testing

Treadmill exercise capacity and other physiologic responses to leg exercise are powerful predictors of mortality and provide important clinical and diagnostic information. However, many Veterans cannot perform treadmill exercise because of lower extremity or other disabilities. For many years, pharmacologic myocardial perfusion imaging (MPI) has been the standard of care for their evaluation but fails to provide powerful prognostic and clinically relevant information of exercise testing, requires exposure to ionizing radiation, and is several times more expensive than exercise electrocardiography (ECG). With a recently completed Merit Review award, we obtained substantial retrospective observational evidence that arm exercise ECG stress testing scores are at least equivalent to pharmacologic MPI for robust prediction of mortality and other measures of clinical outcome in Veterans who cannot perform leg exercise.

PI: Dr.Wade Martin

Study Coordinator: Maria Woodson

This study is currently enrolling. To learn more about the Arm Exercise Study and how you can join contact our research office at (314) 289-7690.